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2016-34
Relating Metals Exposure to Birth and Early Childhood Outcomes via the Metabotype of Cord Blood
Outside United StatesPregnancyChild
The Proposed CHEAR study will study metals exposure in pregnant mothers to birth and early chidlhood outcomes in a Bangladeshi birth cohort. We will assess differences in anthropomorphic birth outcomes based on cord blood metabolite profiles acquired using a targeted 1H NMR-based platform. We will utilize established as well as novel analytic approaches in the field of metabolomics.
Study analytics
Ranges of measured exposures and phenotypes, and the most prevalent untargeted features in this study.
Phenotype ranges
10 phenotypes| Phenotype | Range | Median | n |
|---|---|---|---|
| parityParity | 1 | 267 | |
| birthweightBirth weight | 2.91 | 267 | |
| birthlengthChild birthlength | 46 | 267 | |
| weightadm weight | 45 | 267 | |
| heightadm height | 151 | 267 | |
| wateras_c1Drinking water arsenic at enrollement | 1.8 | 267 | |
| LNAS_C1Natural log of drinking water arsenic at enrollment | 0.588 | 267 | |
| cordblood_asCord blood arsenic level | 0.504 | 267 | |
| bmiBody Mass Index | 20.085 | 266 | |
| headcircumferencechild head circumference | 32 | 266 |
Most prevalent HRMS features
top 20 by detectionC0
m/z 162.1125 · pos
C10
m/z 316.2482 · pos
C10:1
m/z 314.2326 · pos
C10:2
m/z 312.2169 · pos
C12
m/z 344.2795 · pos
C12:1
m/z 342.2639 · pos
C12 / C10
— · pos
C12 / C12:1
— · pos
C12 / C8
— · pos
C12-DC
m/z 374.2537 · pos
C14
m/z 372.3108 · pos
C14:1
m/z 370.2952 · pos
C14:1-OH
m/z 386.2901 · pos
C14:1-OH / C10
— · pos
C14:2
m/z 368.2795 · pos
C14:2-OH
m/z 384.2745 · pos
C14 / C16:1
— · pos
C16
m/z 400.3421 · pos
C16:1
m/z 398.3265 · pos
C16:1-OH
m/z 414.3214 · pos