Evaluation of Environmental Exposures in TEDDY
The Environmental Determinants of Diabetes in the Young (TEDDY) is a multicenter prospective cohort study that started in 2004 and is following 8,676 children at increased genetic risk enrolled before 3 months of age and followed to 15 years of age in order to identify genetic and environmental triggers of type 1 diabetes (T1D) including infectious agents, dietary, and psychosocial factors. The TEDDY study is comprised of six clinical center in the United States, Germany, Finland, and Sweden. TEDDY designed two nested case-control studies, which include children who have developed islet autoantibodies or have been diagnosed with T1D, and their age-matched controls. TEDDY seeks to test the hypothesis that there are differences between cases and controls in trace elements, cytokine and chemokine levels, urinary phthalate metabolite concentrations, and urinary phenols.
Exposures & analytes
Health outcomes
Demographics
Study analytics
Ranges of measured exposures and phenotypes, and the most prevalent untargeted features in this study.
Exposure ranges
44 analytes| Analyte | Range (log) | Median | n |
|---|---|---|---|
| Alng/ml | 16.2 | 1025 | |
| Asng/ml | 8.39 | 1025 | |
| BDCPPng/mL | 0.85 | 1025 | |
| BP3ng/mL | 4.85 | 1025 | |
| BPAng/mL | 1.38 | 1025 | |
| BPFng/mL | 0.254 | 1025 | |
| BPSng/mL | 0.172 | 1025 | |
| BUPBng/mL | 0.088 | 1025 | |
| Bang/ml | 1.89 | 1025 | |
| Cdng/ml | 0.077 | 1025 | |
| Cong/ml | 0.352 | 1025 | |
| Crng/ml | 0.464 | 1025 | |
| Csng/ml | 6.64 | 1025 | |
| Cung/ml | 11.6 | 1025 | |
| DPHPng/mL | 1.16 | 1025 | |
| ETPBng/mL | 0.817 | 1025 | |
| Hgng/ml | 0.404 | 1025 | |
| MBZPng/ml | 7.99 | 1025 | |
| MCPPng/ml | 2.64 | 1025 | |
| MECPPng/ml | 17.8 | 1025 | |
| MEHHPng/ml | 12 | 1025 | |
| MEHPng/ml | 1.93 | 1025 | |
| MEOHPng/ml | 11 | 1025 | |
| MEPng/ml | 9.23 | 1025 | |
| MEPBng/mL | 10.7 | 1025 | |
| MIBPng/ml | 15.9 | 1025 | |
| MNBPng/ml | 18.1 | 1025 | |
| Mgng/ml | 8.9e+4 | 1025 | |
| Mnng/ml | 0.506 | 1025 | |
| Mong/ml | 72.5 | 1025 | |
| NAP1ng/mL | 588 | 1025 | |
| NAP2ng/mL | 1.7e+3 | 1025 | |
| Ning/ml | 1.3 | 1025 | |
| PBAng/mL | 0.186 | 1025 | |
| PRPBng/mL | 0.922 | 1025 | |
| PYR1ng/mL | 80 | 1025 | |
| Pbng/ml | 0.564 | 1025 | |
| Sbng/ml | 0.13 | 1025 | |
| Snng/ml | 0.775 | 1025 | |
| TCCng/mL | 2.0e-3 | 1025 | |
| TCSng/mL | 0.526 | 1025 | |
| Tlng/ml | 0.321 | 1025 | |
| Vng/ml | 0.363 | 1025 | |
| Znng/ml | 362 | 1025 |
Phenotype ranges
39 phenotypes| Phenotype | Range | Median | n |
|---|---|---|---|
| cc | 4 | 350 | |
| HLA_Category | 2 | 350 | |
| weight_kg | 9.95 | 350 | |
| bmi_12mo | 17.206 | 350 | |
| waz_12mo | -0.038 | 350 | |
| visit_1 | 54 | 350 | |
| draw_dte_agedys_1 | 1.6e+3 | 350 | |
| bmi_1 | 16.042 | 350 | |
| bmiz_1 | 0.389 | 350 | |
| PC1 | 3.5e-3 | 349 | |
| PC2 | 9.0e-4 | 349 | |
| visit_2 | 57 | 244 | |
| draw_dte_agedys_2 | 1.7e+3 | 244 | |
| bmi_2 | 15.71 | 244 | |
| bmiz_2 | 0.165 | 244 | |
| visit_3 | 60 | 175 | |
| draw_dte_agedys_3 | 1.9e+3 | 175 | |
| bmi_3 | 15.665 | 175 | |
| bmiz_3 | 0.193 | 175 | |
| CHEAR_IA_case_ind_2 | 102 | 134 | |
| CHEAR_IA_case_endptage_2 | 2.2e+3 | 134 | |
| visit_4 | 66 | 120 | |
| draw_dte_agedys_4 | 2.0e+3 | 120 | |
| bmi_4 | 15.684 | 120 | |
| bmiz_4 | 0.234 | 120 | |
| CHEAR_IA_case_ind_1 | 129.5 | 98 | |
| CHEAR_IA_case_endptage_1 | 2.2e+3 | 98 | |
| visit_5 | 72 | 77 | |
| draw_dte_agedys_5 | 2.2e+3 | 77 | |
| bmi_5 | 15.621 | 77 | |
| bmiz_5 | 0.165 | 77 | |
| CHEAR_T1D_case_ind_2 | 47 | 71 | |
| CHEAR_T1D_case_endptage_2 | 2.3e+3 | 71 | |
| CHEAR_T1D_case_ind_1 | 53.5 | 62 | |
| CHEAR_T1D_case_endptage_1 | 2.1e+3 | 62 | |
| visit_6 | 78 | 38 | |
| draw_dte_agedys_6 | 2.4e+3 | 38 | |
| bmi_6 | 15.761 | 38 | |
| bmiz_6 | 0.188 | 38 |