The Dynamics of Exposure, Phthalates and Asthma in a Randomized Trial (DEPART)

The Dynamics of Exposure, Phthalates, and Asthma project (DEPART) utilizes data and samples collected within the Home Air in Agriculture Pediatric Intervention Trial (HAPI, NIEHS R01 ES023510). The participants are 70 Latino children with asthma aged 6-12 years who reside in rural, agricultural central WA State. They were recruited from 2015-2017 for a one-year follow up period of their asthma morbidity following randomization into a control group (education) or intervention (education plus 2 in home portable HEPA air cleaners). Follow assessments include 2 time points prior to randomization and 2 post randomization and includes collection of urine specimens. The objective of DEPART is to examine associations between urinary biomarkers for emerging contaminants of concern including phthalates, pesticides, and phenols and biomarkers of oxidative stress and inflammation in this population. DEPART also includes metabolomic profiling to investigate potential additional biological mechanisms of toxicity associated with these exposures.